TwoB or not twoB: differential transmission at glutamatergic mossy fiber-interneuron synapses in the hippocampus

Trends Neurosci. 2002 Dec;25(12):600-3. doi: 10.1016/s0166-2236(02)02259-2.


Mossy fiber (MF) synapses are key stations for flow of information through the hippocampal formation. A major component of the output of the MF system is directed towards inhibitory interneurons. Recent studies have revealed that the functional properties of MF-interneuron synapses differ substantially from those of MF-CA3 pyramidal neuron synapses. Mossy-fiber-interneuron synapses in the stratum lucidum represent a continuum of functional subtypes, in which the subunit composition of postsynaptic AMPA receptors and NMDA receptors appears to be regulated in a coordinated manner.

Publication types

  • Review

MeSH terms

  • Animals
  • Interneurons / physiology*
  • Mossy Fibers, Hippocampal / physiology*
  • Pyramidal Cells / physiology
  • Receptors, AMPA / physiology
  • Receptors, N-Methyl-D-Aspartate / physiology
  • Synapses / physiology*
  • Synaptic Transmission / physiology*


  • Receptors, AMPA
  • Receptors, N-Methyl-D-Aspartate