Head trauma and Alzheimer's disease

J Alzheimers Dis. 2002 Aug;4(4):303-8. doi: 10.3233/jad-2002-4405.


The authors describe a case of a 55 year old woman who was diagnosed with Alzheimer's disease 1.5 years after a car accident in which she experienced a mild concussion. Extensive history taking disclosed no cognitive changes prior to the car accident. The case is discussed in view of the inflammation hypothesis regarding Alzheimer's disease and the role of the apolipoprotein E4 genotype of the patient.

Publication types

  • Case Reports

MeSH terms

  • Alzheimer Disease / etiology*
  • Apolipoprotein E4
  • Apolipoproteins E / genetics
  • Atrophy
  • Brain Concussion / complications*
  • Cerebral Cortex / pathology
  • Disease Progression
  • Female
  • Genotype
  • Hippocampus / pathology
  • Humans
  • Magnetic Resonance Imaging
  • Mental Status Schedule
  • Middle Aged
  • Neuropsychological Tests
  • Risk Factors


  • Apolipoprotein E4
  • Apolipoproteins E