Protein kinase CK2 and regulation of Ca2+-ATPase activity in brain neuron chromatin in rats during aging

B A Reikhardt; O G Kulikova; N S Sapronov

doi:10.1023/a:1020277607879

Protein kinase CK2 and regulation of Ca2+-ATPase activity in brain neuron chromatin in rats during aging

Bull Exp Biol Med. 2002 Jun;133(6):565-7. doi: 10.1023/a:1020277607879.

Authors

B A Reikhardt¹, O G Kulikova, N S Sapronov

Affiliation

¹ Department of Neuropharmacology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg.

PMID: 12447466
DOI: 10.1023/a:1020277607879

Abstract

Protein kinase CK2 from neuronal chromatin phosphorylates myosin-like proteins isolated from rat brain chromatin. The protein kinase CK2 activator 1-ethyl-4,5-di(N-methylcarbamoyl)imidazole in vitro stimulated phosphorylation of myosin-like proteins and increased myosin-type Ca(2+)-ATPase activity in neuronal chromatin. After systemic administration this agent normalized Ca(2+)-ATPase activity of brain chromatin in aged rats.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aging / metabolism*
Animals
Brain / metabolism*
Calcium-Transporting ATPases / metabolism*
Casein Kinase II
Chromatin / enzymology
Chromatin / metabolism*
Enzyme Activation
Male
Neurons / enzymology
Neurons / metabolism
Phosphorylation
Protein Serine-Threonine Kinases / metabolism*
Rats

Substances

Chromatin
Casein Kinase II
Protein Serine-Threonine Kinases
Calcium-Transporting ATPases