In vitro effect of short peptides on expression of interleukin-2 gene in splenocytes

T B Kazakova; S V Barabanova; V Kh Khavinson; M S Glushikhina; E P Parkhomenko; V V Malinin; E A Korneva

doi:10.1023/a:1020210615148

In vitro effect of short peptides on expression of interleukin-2 gene in splenocytes

Bull Exp Biol Med. 2002 Jun;133(6):614-6. doi: 10.1023/a:1020210615148.

Authors

T B Kazakova¹, S V Barabanova, V Kh Khavinson, M S Glushikhina, E P Parkhomenko, V V Malinin, E A Korneva

Affiliation

¹ Department of General Pathology and Pathophysiology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg.

PMID: 12447482
DOI: 10.1023/a:1020210615148

Abstract

Synthetic peptides Vilon (Lys-Glu), Epithalon (Ala-Glu-Asp-Gly), and Cortagen (Ala-Glu-Asp-Pro) in vitro activated interleukin-2 mRNA synthesis in splenocytes from CBA mice in the absence of specific inductors. The intensity of interleukin-2 mRNA synthesis in splenocytes depended on the type, concentration, and duration of treatment with the peptides. Vilon and Epithalon were most potent, while Cortagen produced a less pronounced effect on interleukin-2 mRNA synthesis.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cells, Cultured
Dipeptides / pharmacology
Dose-Response Relationship, Drug
Gene Expression / drug effects
Interleukin-2 / genetics*
Mice
Mice, Inbred CBA
Oligopeptides / pharmacology
Peptides / chemistry
Peptides / pharmacology*
Spleen / cytology*
Spleen / drug effects
Time Factors

Substances

Dipeptides
Interleukin-2
Oligopeptides
Peptides
alanyl-glutamyl-aspartylprolyine
lysylglutamic acid
alanyl-glutamyl-aspartyl-glycine