Gastric collision between a papillotubular adenocarcinoma and a gastrinoma in a patient with Zollinger-Ellison syndrome

Virchows Arch. 2002 Nov;441(5):462-5. doi: 10.1007/s00428-002-0707-9. Epub 2002 Aug 29.

Abstract

We report a unique case of a gastric collision tumor composed of an intramural gastrin-secreting tumor and a papillotubular adenocarcinoma of the intestinal type discovered at autopsy in a patient with Zollinger-Ellison syndrome. There was extensive metastatic dissemination of the neuroendocrine component to regional lymph nodes and to the liver. The unusual macroscopical, histological, and immunohistochemical features of this case and its specific clinical setting are discussed.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / chemistry
  • Adenocarcinoma / secondary*
  • Adenocarcinoma, Papillary / chemistry
  • Adenocarcinoma, Papillary / secondary*
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor / analysis
  • Chromogranin A
  • Chromogranins / analysis
  • Fatal Outcome
  • Humans
  • Immunoenzyme Techniques
  • Liver Neoplasms / secondary
  • Lymph Nodes / pathology
  • Lymphatic Metastasis
  • Male
  • Neoplasms, Multiple Primary*
  • Phosphopyruvate Hydratase / analysis
  • Stomach Neoplasms / chemistry
  • Stomach Neoplasms / pathology*
  • Zollinger-Ellison Syndrome / metabolism
  • Zollinger-Ellison Syndrome / pathology*

Substances

  • Biomarkers, Tumor
  • Chromogranin A
  • Chromogranins
  • Phosphopyruvate Hydratase