Ultrastructural analysis of pancreatic acinar cells from mice fed on genetically modified soybean

J Anat. 2002 Nov;201(5):409-15. doi: 10.1046/j.0021-8782.2002.00103.x.


No direct evidence that genetically modified (GM) food may represent a possible danger for health has been reported so far; however, the scientific literature in this field is quite poor. Therefore, we investigated the possible effects of a diet containing GM soybean on mouse exocrine pancreas by means of ultrastructural, morphometrical and immunocytochemical analyses. Our observations demonstrate that, although no structural modification occurs in pancreatic acinar cells of mice fed on GM soybean, quantitative changes of some cellular constituents take place in comparison to control animals. In particular, a diet containing significant amount of GM food seems to influence the zymogen synthesis and processing.

MeSH terms

  • Animals
  • Cell Nucleus / ultrastructure
  • Endoplasmic Reticulum, Rough / ultrastructure
  • Female
  • Food, Genetically Modified*
  • Golgi Apparatus / ultrastructure
  • Image Processing, Computer-Assisted*
  • Mice
  • Mice, Inbred Strains
  • Microscopy, Electron
  • Pancreas / chemistry
  • Pancreas / ultrastructure*
  • Secretory Vesicles / ultrastructure
  • Soybeans*
  • Spectrophotometry
  • alpha-Amylases / analysis


  • alpha-Amylases