Consumption of diacylglycerol oil as part of a reduced-energy diet enhances loss of body weight and fat in comparison with consumption of a triacylglycerol control oil

Am J Clin Nutr. 2002 Dec;76(6):1230-6. doi: 10.1093/ajcn/76.6.1230.


Background: Diacylglycerol is a natural component of edible oils that has metabolic characteristics that are distinct from those of triacylglycerol.

Objective: We assessed the efficacy of an oil containing mainly 1,3-diacylglycerol in reducing body weight and fat mass when incorporated into a reduced-energy diet.

Design: The study was a randomized, double-blind, parallel intervention trial that was conducted at an outpatient clinical research center. The subjects (n = 131) were overweight or obese men (waist circumference > or = 90 cm) and women (waist circumference > or = 87 cm). Food products (muffins, crackers, soup, cookies, and granola bars) containing diacylglycerol or triacylglycerol oil and having the same fatty acid composition were incorporated into a reduced-energy diet (2100-3350-kJ/d deficit) for 24 wk. Percentages of change in body weight, fat mass, and intraabdominal fat area were assessed.

Results: In an intention-to-treat analysis, body weight and fat mass decreased significantly more in the diacylglycerol group than in the triacylglycerol group (P = 0.025 and 0.037, respectively). By the end of the trial, mean body weight had decreased 3.6% and 2.5% in the diacylglycerol and triacylglycerol groups, respectively. Fat mass decreased 8.3% and 5.6% in the diacylglycerol and triacylglycerol groups, respectively.

Conclusion: Foods containing diacylglycerol oil promoted weight loss and body fat reduction and may be useful as an adjunct to diet therapy in the management of obesity.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abdomen
  • Adipose Tissue
  • Adult
  • Aged
  • Body Composition
  • Body Constitution
  • Diet
  • Diet, Reducing*
  • Dietary Fats, Unsaturated / administration & dosage*
  • Dietary Fats, Unsaturated / adverse effects
  • Diglycerides / administration & dosage*
  • Diglycerides / adverse effects
  • Double-Blind Method
  • Energy Intake*
  • Exercise
  • Female
  • Humans
  • Lipids / blood
  • Male
  • Middle Aged
  • Obesity / therapy
  • Triglycerides / administration & dosage*
  • Weight Loss*


  • Dietary Fats, Unsaturated
  • Diglycerides
  • Lipids
  • Triglycerides