Relationship between CAG repeat length and late-stage outcomes in Huntington's disease

Neurology. 2002 Nov 26;59(10):1622-4. doi: 10.1212/01.wnl.0000035627.16789.23.

Abstract

The relationship between CAG repeat length and age at nursing home (NH) admission and age at percutaneous endoscopic gastrostomy (PEG) was examined in 47 residents of a specialized Huntington's disease long-term care facility who were observed for a median of 3 years (range, 1 to 11 years). CAG repeat length was inversely correlated with time to NH admission and PEG (both p < 0.001), independent of age at onset. CAG repeat length may influence disease progression to late-stage outcomes in addition to age at onset.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Disease Progression
  • Endoscopy
  • Female
  • Gastrostomy
  • Humans
  • Huntington Disease / genetics*
  • Length of Stay
  • Male
  • Middle Aged
  • Nursing Homes
  • Regression Analysis
  • Repetitive Sequences, Nucleic Acid / genetics*
  • Survival Analysis
  • Weight Loss / physiology