Potential role of anaerobic cocci in impaired human wound healing

Wound Repair Regen. Nov-Dec 2002;10(6):346-53. doi: 10.1046/j.1524-475x.2002.t01-1-10602.x.


Although more than 80% of infected and 70% of noninfected leg ulcers have been shown to harbor anaerobic organisms, their role in mediating impaired wound healing in the skin is frequently overlooked. There is now increasing evidence that the gram-positive anaerobic cocci play a role (both directly and indirectly) in mediating impaired wound healing in vivo. This article discusses the mechanisms by which these microorganisms may interfere with the inflammation, repair, and remodeling phases of the wound healing process.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacteria, Anaerobic / isolation & purification*
  • Bacteria, Anaerobic / pathogenicity
  • Bacteria, Anaerobic / physiology*
  • Gram-Positive Bacterial Infections / complications
  • Gram-Positive Bacterial Infections / microbiology*
  • Gram-Positive Bacterial Infections / physiopathology*
  • Gram-Positive Cocci / isolation & purification*
  • Gram-Positive Cocci / pathogenicity
  • Gram-Positive Cocci / physiology*
  • Humans
  • Leg Ulcer / complications
  • Leg Ulcer / microbiology*
  • Leg Ulcer / physiopathology*
  • Wound Healing / physiology*