Non-compliance and its management in teenagers

Pediatr Transplant. 2002 Dec;6(6):475-9. doi: 10.1034/j.1399-3046.149.ptr1s077.1.x.


Renal transplantation restores a patient's endogenous renal function. The benefits of this restoration are especially dramatic in children. However, transplantation is a complex and expensive therapy which, when successful, requires consistent adherence to a complex regimen of drug therapy and clinical follow-up. Transplant medications need to be taken for a lifetime. Whilst very effective, immunosuppressant medications can also cause a number of side-effects and require daily multi-dose schedules. Teenagers, in particular, have problems adhering to these regimens and weighing the consequences of non-compliance. Approaches to improving teenagers' compliance must address both the special circumstances of adolescence and the broad, general problem of post-transplant non-compliance.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adolescent Behavior
  • Female
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Kidney Transplantation*
  • Male
  • Patient Compliance*
  • Psychology, Adolescent*
  • Treatment Refusal


  • Immunosuppressive Agents