Fatty acid ethyl esters: toxic non-oxidative metabolites of ethanol and markers of ethanol intake

Front Biosci. 2003 Jan 1;8:e202-17. doi: 10.2741/931.

Abstract

This report describes the biochemistry of fatty acid ethyl esters (FAEE), non-oxidative metabolites of ethanol, and their clinical significance. We review information regarding the enzymes responsible for FAEE synthesis and degradation, and the mechanisms involved with the intracellular and extracellular transport of FAEE and FAEE-mediated cytotoxicity. Also a summary of reports on the emerging clinical significance and diagnostic utility of FAEE as short and long-term markers of alcohol consumption, and the methodological aspects of FAEE assessment is included.

Publication types

  • Review

MeSH terms

  • Alcohol Drinking*
  • Animals
  • Biomarkers / blood*
  • Esters / blood*
  • Esters / metabolism
  • Esters / poisoning*
  • Esters / toxicity
  • Ethanol / blood
  • Ethanol / pharmacokinetics*
  • Ethanol / poisoning*
  • Ethanol / toxicity
  • Fatty Acids / blood*
  • Fatty Acids / metabolism
  • Fatty Acids / poisoning*
  • Fatty Acids / toxicity
  • Humans
  • Oxidation-Reduction

Substances

  • Biomarkers
  • Esters
  • Fatty Acids
  • Ethanol