Abstract
Hyperpolarization-activated cation channels (h-channels) are key regulators of neuronal excitation and inhibition, and have a rich diversity of subunit composition, distribution, modulation and function. Recent results indicate that the behavior of h-channels can be altered significantly by seizures. The activity-dependent, short-term and long-term plasticity of h-channels can, in turn, modulate neuronal excitability. The reciprocal interactions between neuronal activity and h-channels indicate that these ion channels could be promising novel targets for anti-epileptic therapies.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Anticonvulsants / pharmacology*
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Brain / drug effects
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Brain / metabolism*
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Cyclic Nucleotide-Gated Cation Channels
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Epilepsy / drug therapy
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Epilepsy / metabolism*
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Humans
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Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
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Ion Channels / antagonists & inhibitors*
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Nerve Tissue Proteins*
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Neuronal Plasticity / drug effects
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Potassium Channels
Substances
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Anticonvulsants
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Cyclic Nucleotide-Gated Cation Channels
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Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
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Ion Channels
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Nerve Tissue Proteins
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Potassium Channels