H-channels in epilepsy: new targets for seizure control?

Trends Pharmacol Sci. 2002 Dec;23(12):552-7. doi: 10.1016/s0165-6147(02)02110-7.


Hyperpolarization-activated cation channels (h-channels) are key regulators of neuronal excitation and inhibition, and have a rich diversity of subunit composition, distribution, modulation and function. Recent results indicate that the behavior of h-channels can be altered significantly by seizures. The activity-dependent, short-term and long-term plasticity of h-channels can, in turn, modulate neuronal excitability. The reciprocal interactions between neuronal activity and h-channels indicate that these ion channels could be promising novel targets for anti-epileptic therapies.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Anticonvulsants / pharmacology*
  • Brain / drug effects
  • Brain / metabolism*
  • Cyclic Nucleotide-Gated Cation Channels
  • Epilepsy / drug therapy
  • Epilepsy / metabolism*
  • Humans
  • Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
  • Ion Channels / antagonists & inhibitors*
  • Nerve Tissue Proteins*
  • Neuronal Plasticity / drug effects
  • Potassium Channels


  • Anticonvulsants
  • Cyclic Nucleotide-Gated Cation Channels
  • Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
  • Ion Channels
  • Nerve Tissue Proteins
  • Potassium Channels