Recent advances in angiogenesis, anti-angiogenesis and vascular targeting

Trends Pharmacol Sci. 2002 Dec;23(12):576-82. doi: 10.1016/s0165-6147(02)02109-0.

Abstract

Angiogenesis, the development of new blood vessels, has become a major focus of research. This has been stimulated by the therapeutic opportunities offered by the ability to manipulate the vasculature in pathologies such as cancer. Here, we present an overview of recent advances in angiogenesis. Especially noteworthy is the large volume of information from developmental studies, particularly those that involve transgenic and gene knockout mice. We also discuss the increasing repertoire of drugs with which to manipulate angiogenesis and new endothelial-specific genes with which to target the vasculature.

Publication types

  • Review

MeSH terms

  • Angiogenesis Inducing Agents / antagonists & inhibitors
  • Angiogenesis Inhibitors / pharmacology*
  • Angiogenesis Inhibitors / therapeutic use
  • Animals
  • Clinical Trials as Topic
  • Endothelial Growth Factors / biosynthesis
  • Endothelium, Vascular / drug effects*
  • Endothelium, Vascular / metabolism
  • Endothelium, Vascular / pathology
  • Humans
  • Intercellular Signaling Peptides and Proteins / biosynthesis
  • Lymphokines / biosynthesis
  • Neoplasms / blood supply*
  • Neoplasms / drug therapy
  • Neoplasms / metabolism
  • Neovascularization, Pathologic / drug therapy*
  • Neovascularization, Pathologic / genetics
  • Neovascularization, Pathologic / metabolism
  • Neovascularization, Physiologic / genetics
  • Neovascularization, Physiologic / physiology*
  • Receptors, Vascular Endothelial Growth Factor / antagonists & inhibitors
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors

Substances

  • Angiogenesis Inducing Agents
  • Angiogenesis Inhibitors
  • Endothelial Growth Factors
  • Intercellular Signaling Peptides and Proteins
  • Lymphokines
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors
  • Receptors, Vascular Endothelial Growth Factor