Treatment outcomes and prognostic factors of patients with supratentorial low-grade oligodendroglioma

Int J Radiat Oncol Biol Phys. 2002 Dec 1;54(5):1405-9. doi: 10.1016/s0360-3016(02)03053-5.


Purpose: Oligodendroglioma is a relatively rare central nervous system tumor. Currently, surgical intervention is the mainstay of treatment, and the role of postoperative radiotherapy (RT) remains a subject of controversy. The objective of this study was to investigate the prognostic factors, evaluate the treatment outcomes, and assess whether postoperative RT has a benefit on local control and overall survival rates.

Methods and materials: This was a retrospective review of 52 consecutive adult patients with supratentorial low-grade oligodendrogliomas diagnosed at our institution between September 1980 and September 1998. Thirty-two received postoperative RT. Data were analyzed retrospectively to survey the significant prognostic factors for local control and overall survival.

Results: The 5-year overall and progression-free survival rate was 80% and 67%, respectively. Twenty-five patients experienced local disease progression during the follow-up period. In multivariate analysis, postoperative RT and age at diagnosis showed independent prognostic significance for overall survival. For progression-free survival, postoperative RT was the only independent prognostic factor.

Conclusion: On the basis of the results of this study, we recommend considering postoperative RT as one of the standard adjuvant treatment modalities for patients with supratentorial low-grade oligodendroglioma, regardless of the extent of surgical resection. The optimal treatment strategy to maximize the treatment outcome should still be explored.

MeSH terms

  • Adult
  • Age of Onset
  • Aged
  • Brain Neoplasms / diagnosis
  • Brain Neoplasms / radiotherapy*
  • Brain Neoplasms / surgery*
  • Combined Modality Therapy
  • Disease Progression
  • Disease-Free Survival
  • Female
  • Humans
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Oligodendroglioma / diagnosis
  • Oligodendroglioma / radiotherapy*
  • Oligodendroglioma / surgery*
  • Prognosis
  • Retrospective Studies
  • Time Factors
  • Treatment Outcome