The Retinoblastoma Tumour Suppressor in Development and Cancer

Nat Rev Cancer. 2002 Dec;2(12):910-7. doi: 10.1038/nrc950.

Abstract

Since its discovery, the retinoblastoma (RB) tumour-suppressor protein has been a focal point of cancer research. Accumulating evidence indicates a complex role for RB in cell proliferation, differentiation and survival. To further complicate matters, proteins that are related to RB have redundant as well as antagonistic functions. Recent studies of knockout mice and cells that lack one or more of these proteins have begun to clarify their various context-specific functions and the unique activity of this tumour suppressor.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Division
  • Genes, Retinoblastoma*
  • Humans
  • Mice
  • Mice, Knockout
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism
  • Phenotype
  • Phosphoproteins / genetics
  • Phosphoproteins / metabolism
  • Proteins*
  • Retinoblastoma / genetics
  • Retinoblastoma / metabolism*
  • Retinoblastoma / pathology
  • Retinoblastoma Protein / genetics
  • Retinoblastoma Protein / metabolism*
  • Retinoblastoma-Like Protein p107
  • Retinoblastoma-Like Protein p130
  • Signal Transduction

Substances

  • Nuclear Proteins
  • Phosphoproteins
  • Proteins
  • RBL2 protein, human
  • Rbl1 protein, mouse
  • Rbl2 protein, mouse
  • Retinoblastoma Protein
  • Retinoblastoma-Like Protein p107
  • Retinoblastoma-Like Protein p130