Molecular mechanisms of novel therapeutic approaches for multiple myeloma

Nat Rev Cancer. 2002 Dec;2(12):927-37. doi: 10.1038/nrc952.


Multiple myeloma remains largely incurable despite conventional and high-dose therapies, and so novel biologically based treatment approaches are urgently required. Recent studies have characterized the molecular mechanisms by which multiple myeloma cell-host bone-marrow interactions regulate tumour cell growth, survival and migration in the bone-marrow microenvironment. These studies have not only enhanced our understanding of disease pathogenesis, but have also provided the framework for a new treatment model that targets the multiple myeloma cell in its bone-marrow microenvironment to overcome drug resistance and improve patient outcome.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / pharmacology
  • Apoptosis / drug effects
  • Bone Diseases / complications
  • Bone Diseases / therapy
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Multiple Myeloma / complications
  • Multiple Myeloma / metabolism*
  • Multiple Myeloma / pathology
  • Multiple Myeloma / therapy*
  • Oligonucleotide Array Sequence Analysis
  • Signal Transduction / drug effects


  • Enzyme Inhibitors