Recurrence of hemolytic uremic syndrome after live related renal transplantation associated with subsequent de novo disease in the donor

Am J Kidney Dis. 2002 Dec;40(6):E22. doi: 10.1053/ajkd.2002.36938.


There is a significant risk of disease recurrence in patients with nondiarrheal (D-) hemolytic uremic syndrome (HUS) undergoing renal transplantation. Recent studies have found that approximately 20% of sporadic cases of HUS have mutations in the gene for the complement regulatory protein factor H. The authors report on 2 families, in each of which a family member initially presented with sporadic HUS and subsequently received a live-related renal transplant, one from a sibling and the other from the father. Subsequently, both recipients suffered recurrent HUS in the allograft, and both donors had HUS within a year of the transplant. Neither family has a factor H mutation. This report underlines the risk of disease recurrence in recipients associated with live-related renal transplantation in HUS and also suggests that the donors may be at risk.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Child, Preschool
  • Female
  • Hemolytic-Uremic Syndrome / etiology*
  • Humans
  • Kidney Transplantation / adverse effects*
  • Kidney Transplantation / methods
  • Living Donors*
  • Male
  • Nuclear Family*
  • Recurrence
  • Transplantation, Homologous / methods