Amphotericin B lipid complex exerts additive antifungal activity in combination with polymorphonuclear leucocytes against Scedosporium prolificans and Scedosporium apiospermum

J Antimicrob Chemother. 2002 Dec;50(6):1027-30. doi: 10.1093/jac/dkf198.


Scedosporium prolificans and Scedosporium apiospermum are resistant to most antifungal agents and cause refractory pulmonary and disseminated infections. The combined effects of deoxycholate amphotericin B, amphotericin B lipid complex and liposomal amphotericin B with human polymorphonuclear leucocytes (PMNs) in damaging hyphae of these fungi were evaluated by XTT assay. Amphotericin B lipid complex displayed a significant additive effect with PMNs against both Scedosporium species (22% for S. prolificans and 81% for S. apiospermum; P < 0.04). None of the formulations adversely affected the PMN antifungal activity. These findings may be important in designing better strategies for management of infections due to these organisms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amphotericin B / pharmacology*
  • Antifungal Agents / pharmacology*
  • Drug Combinations
  • Drug Therapy, Combination
  • Humans
  • Neutrophils / microbiology*
  • Phosphatidylcholines / pharmacology*
  • Phosphatidylglycerols / pharmacology*
  • Scedosporium / drug effects*
  • Scedosporium / isolation & purification
  • Statistics, Nonparametric


  • Antifungal Agents
  • Drug Combinations
  • Phosphatidylcholines
  • Phosphatidylglycerols
  • liposomal amphotericin B
  • Amphotericin B