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Comment
. 2002 Dec 10;99(25):15837-9.
doi: 10.1073/pnas.012685199. Epub 2002 Dec 2.

The jaundice of the cell

David A Greenberg  1
Affiliations
Comment

The jaundice of the cell

David A Greenberg. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
Synthesis of bilirubin from heme. HO, heme oxygenase; BVR, biliverdin reductase; CO, carbon monoxide.
Fig. 2.
Fig. 2.
Physiological jaundice of the newborn (photo courtesy of Maeve Greenberg).
Fig. 3.
Fig. 3.
Amplification of the neuroprotective effect of bilirubin by redox cycling. Biliverdin is reduced to bilirubin by biliverdin reductase (BVR) and is regenerated when the detoxification of reactive oxygen species (ROS) oxidizes bilirubin back to biliverdin. In this manner, low concentrations of bilirubin can be recycled to neutralize large amounts of ROS.
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