Sorting out the cellular functions of sorting nexins

Nat Rev Mol Cell Biol. 2002 Dec;3(12):919-31. doi: 10.1038/nrm974.


Sorting nexins are a diverse group of cellular trafficking proteins that are unified by the presence of a phospholipid-binding motif - the PX domain. The ability of these proteins to bind specific phospholipids, as well as their propensity to form protein-protein complexes, points to a role for these proteins in membrane trafficking and protein sorting. It will be interesting to determine whether the various sorting nexins have specialized or generalized roles in protein trafficking.

Publication types

  • Review

MeSH terms

  • Amino Acid Motifs
  • Amino Acid Sequence
  • Biological Transport / physiology*
  • Carrier Proteins / classification
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism*
  • Cell Membrane / metabolism
  • Cytoplasmic Vesicles / metabolism
  • Humans
  • Models, Biological
  • Models, Molecular
  • Molecular Sequence Data
  • Phospholipids / metabolism
  • Phylogeny
  • Protein Binding
  • Protein Structure, Tertiary
  • Protein Transport*
  • Vesicular Transport Proteins*
  • Yeasts / physiology


  • Carrier Proteins
  • Phospholipids
  • Vesicular Transport Proteins