uPAR: a versatile signalling orchestrator

Nat Rev Mol Cell Biol. 2002 Dec;3(12):932-43. doi: 10.1038/nrm977.


The plasminogen system has been implicated in clot lysis, wound healing, tissue regeneration, cancer and many other processes that affect health and disease. The urokinase receptor uPAR was originally thought to assist the directional invasion of migrating cells, but it is now becoming increasingly evident that this proteinase receptor elicits a plethora of cellular responses that include cellular adhesion, differentiation, proliferation and migration in a non-proteolytic fashion.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Adhesion / physiology
  • Cell Differentiation / physiology
  • Cell Division / physiology
  • Cell Movement / physiology*
  • Gene Targeting
  • Humans
  • Integrins / metabolism
  • Models, Biological
  • Neoplasms / metabolism
  • Neovascularization, Pathologic / metabolism
  • Plasminogen Activators / metabolism*
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / metabolism*
  • Receptors, Urokinase Plasminogen Activator
  • Signal Transduction / physiology*
  • Urokinase-Type Plasminogen Activator / metabolism


  • Integrins
  • PLAUR protein, human
  • Receptors, Cell Surface
  • Receptors, Urokinase Plasminogen Activator
  • Plasminogen Activators
  • Urokinase-Type Plasminogen Activator