Regulation of B-cell fate by antigen-receptor signals

Nat Rev Immunol. 2002 Dec;2(12):945-56. doi: 10.1038/nri955.


Recent evidence indicates that B cells are instructed continuously by B-cell receptor (BCR) signals to make crucial cell-fate decisions at several checkpoints during their development. Targeted disruption of BCR signalling components leads to distinct blocks in B-cell maturation, which indicates that key kinases and adaptors fine-tune BCR signalling to direct appropriate cell fates. Recent progress in unravelling the molecular mechanisms of the BCR signalling pathways has helped to clarify how BCR signals regulate the proliferation, survival and apoptosis of developing B cells.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antibody Formation
  • Apoptosis / immunology
  • B-Lymphocytes / cytology
  • B-Lymphocytes / immunology*
  • Cell Division / immunology
  • Cell Survival / immunology
  • Gene Deletion
  • Humans
  • Lymphopoiesis
  • Membrane Microdomains / metabolism
  • Receptors, Antigen, B-Cell / genetics
  • Receptors, Antigen, B-Cell / metabolism
  • Receptors, Antigen, B-Cell / physiology*
  • Signal Transduction / immunology*


  • Receptors, Antigen, B-Cell