Cloning, expression and characterization of a novel human VMP gene

Mol Biol Rep. 2002 Sep;29(3):281-6. doi: 10.1023/a:1020402410522.


We report here cloning and characterization of a novel human gene, termed VMP, which is a vesicular membrane protein. RT-PCR analysis shows that VMP is expressed exclusively in brain of the 16 tissues examined, suggesting that it is a neuron-specific membrane protein. The cDNA encodes 195 amino acid with a putative molecular weight of about 24 KDa. VMP contains two putative membrane spanning domains and a hydrophilic tail homologous to the microtubule-binding domain of MAPs. So it is speculated that VMP may associated with microtubules through its C-terminal and plays an important role in vesicular organelles transport and nerve signals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Cloning, Molecular
  • DNA, Complementary / chemistry
  • DNA, Complementary / isolation & purification*
  • Humans
  • Membrane Proteins / genetics*
  • Membrane Proteins / metabolism
  • Microtubule-Associated Proteins / genetics
  • Molecular Sequence Data
  • Molecular Weight
  • Neurons / chemistry
  • Protein Structure, Tertiary
  • Tissue Distribution


  • DNA, Complementary
  • Membrane Proteins
  • Microtubule-Associated Proteins
  • NRSN1 protein, human

Associated data

  • GENBANK/AF418980