Ankylosing spondylitis--cardiac manifestations

Clin Exp Rheumatol. 2002 Nov-Dec;20(6 Suppl 28):S11-5.


There is a definite association of heart disease with ankylosing spondylitis (AS). The magnitude of this relationship is less clear. Three types of inflammatory affections can be differentiated: 1. aortitis and aortic insufficiency with the possible necessity of cardiac surgery, 2. conduction disturbances of the atrioventricular node with a probable subsequent indication for a pacemaker and 3. myocardial involvement with a possible compromise of left ventricular function. There seems to be an HLA B27-associated cardiac syndrome consisting of aortic root disease and conduction abnormalities. Patients can be recognized at pre-clinical stages. Prospective studies have not been performed. HLA B27-related heart disease does not seem to be associated with increased mortality.

Publication types

  • Review

MeSH terms

  • Aortic Diseases / etiology*
  • Heart Conduction System / physiopathology
  • Heart Diseases / etiology*
  • Humans
  • Spondylitis, Ankylosing / complications*
  • Spondylitis, Ankylosing / physiopathology
  • Ventricular Dysfunction, Left / etiology