Peroxisome biogenesis and protein import in plants, animals and yeasts: enigma and variations? (Review)

Mol Membr Biol. Jul-Sep 2002;19(3):171-85. doi: 10.1080/09687680210159422.


Peroxisomes are found in virtually all eukaryotic cells, where they play varied but essential metabolic roles, exemplified by the catastrophic effects of mutations that compromise peroxisome biogenesis and function. This review will aim to provide an accessible introduction to peroxisome biogenesis and protein import for the non-specialist, and draws together recent advances in peroxisome protein targeting and import in plants, animals and yeasts, seeking to define common themes and highlight variations. Despite much progress, many aspects of peroxisome biology remain an enigma, and current questions and controversies in the field are highlighted and discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cytosol / metabolism
  • Extracellular Matrix Proteins / metabolism
  • Fungal Proteins / metabolism
  • Membrane Proteins / metabolism
  • Molecular Sequence Data
  • Peroxisomal Targeting Signal 2 Receptor
  • Peroxisome-Targeting Signal 1 Receptor
  • Peroxisomes / metabolism*
  • Peroxisomes / physiology
  • Plants / metabolism*
  • Protein Transport
  • Receptors, Cytoplasmic and Nuclear / metabolism
  • Sequence Homology, Amino Acid
  • Signal Transduction
  • Yeasts / metabolism*


  • Extracellular Matrix Proteins
  • Fungal Proteins
  • Membrane Proteins
  • PMP47 protein, Candida boidinii
  • Peroxisomal Targeting Signal 2 Receptor
  • Peroxisome-Targeting Signal 1 Receptor
  • Receptors, Cytoplasmic and Nuclear