Alpha1-antitrypsin polymerization and the serpinopathies: pathobiology and prospects for therapy

J Clin Invest. 2002 Dec;110(11):1585-90. doi: 10.1172/JCI16782.

Authors

David A Lomas¹, Ravi Mahadeva

Affiliation

¹ Respiratory Medicine Unit, Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Cambridge, United Kingdom. dal16@cam.ac.uk

PMID: 12464660
PMCID: PMC151637
DOI: 10.1172/JCI16782

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Humans
Liver / metabolism
Liver / pathology
Macromolecular Substances
Models, Molecular
Protein Structure, Secondary
Serine Proteinase Inhibitors / chemistry
Serine Proteinase Inhibitors / metabolism*
Serpins / metabolism
alpha 1-Antitrypsin / chemistry
alpha 1-Antitrypsin / metabolism*
alpha 1-Antitrypsin Deficiency / metabolism
alpha 1-Antitrypsin Deficiency / pathology

Substances

Macromolecular Substances
Serine Proteinase Inhibitors
Serpins
alpha 1-Antitrypsin