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, 46 (6), 259-67

Antihypertensive Effects of Hydrolysates of Wakame (Undaria Pinnatifida) and Their angiotensin-I-converting Enzyme Inhibitory Activity

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Antihypertensive Effects of Hydrolysates of Wakame (Undaria Pinnatifida) and Their angiotensin-I-converting Enzyme Inhibitory Activity

Minoru Sato et al. Ann Nutr Metab.

Abstract

Aim: The angiotensin-I-converting enzyme (ACE) inhibitory and antihypertensive activities of wakame hydrolysates have been investigated in several studies.

Methods: Wakame (Undaria pinnatifida) was hydrolyzed using 17 kinds of proteases and the inhibitory activity of the hydrolysates for ACE was measured. Of these hydrolysates 4 with potent ACE inhibitory activity were administered singly and orally to spontaneously hypertensive rats (SHR).

Results: The systolic blood pressure of SHR decreased significantly after single oral administration of protease S 'Amano' and proleather FG-F hydrolysates (10 mg protein/kg body weight). In a long-term feeding experiment, 7-week-old SHR were fed standard chow supplemented with protease S 'Amano'-derived wakame hydrolysates for 10 weeks. In SHR fed the 1 and 0.1% wakame hydrolysates, elevation of systolic blood pressure was still significantly suppressed for 7 weeks.

Conclusions: The hydrolysates derived from wakame by protease S 'Amano' have a powerful ACE-inhibitory activity (IC(50) = 86 microg protein/ml) and were effective in spite of their slight bitterness as 'physiologically functional food' with antihypertensive activity.

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