Inhibitory effect of polaprezinc on the inflammatory response to Helicobacter pylori

Can J Gastroenterol. 2002 Nov;16(11):785-9. doi: 10.1155/2002/631070.


Helicobacter pylori-infected gastrointestinal mucosa is frequently infiltrated by polymorphonuclear leukocytes (PMN) and monocytes, and these invading cells have been implicated in gastrointestinal mucosal inflammation. To clarify the efficacy of polaprezinc, a chelate compound consisting of zinc and L-carnosine, against H pylori-induced inflammation including PMN infiltration, the in vitro effects of this drug on interleukin (IL)-8 production by an established gastric cancer cell line (MKN 45 cells) and on PMN-endothelial cell adhesive interactions was investigated. Polaprezinc and zinc sulphate inhibited IL-8 production by MKN 45 cells in response to stimulation with H pylori water extract (HPE) in a dose-dependent manner from 10(-7) M to 10(-5) M. In addition, the expression of CD11b and CD18 on PMN and PMN-dependent adhesion to endothelial cells elicited by HPE was inhibited by polaprezinc and zinc sulphate in a concentration-dependent manner. L-carnosine did not have any effects on IL-8 production or PMN-endothelial cell interactions. These results suggest that polaprezinc, mainly the zinc component, may inhibit H pylori-induced PMN-mediated gastric inflammation by attenuating CD11b/CD18 expression on PMN and IL-8 production from gastric epithelial cells.

MeSH terms

  • Anti-Inflammatory Agents / pharmacology*
  • Anti-Inflammatory Agents / therapeutic use
  • Anti-Ulcer Agents / pharmacology*
  • Anti-Ulcer Agents / therapeutic use
  • Astringents / pharmacology*
  • Astringents / therapeutic use
  • Carnosine / analogs & derivatives*
  • Carnosine / pharmacology*
  • Carnosine / therapeutic use
  • Cell Adhesion / drug effects
  • Helicobacter pylori / drug effects*
  • Helicobacter pylori / pathogenicity*
  • Humans
  • In Vitro Techniques
  • Inflammation / complications
  • Inflammation / drug therapy*
  • Inflammation / etiology*
  • Interleukin-8 / analysis
  • Neutrophils / drug effects
  • Organometallic Compounds / pharmacology*
  • Organometallic Compounds / therapeutic use
  • Stomach Neoplasms / etiology*
  • Stomach Neoplasms / prevention & control*
  • Tumor Cells, Cultured / drug effects
  • Zinc Compounds
  • Zinc Sulfate / pharmacology*
  • Zinc Sulfate / therapeutic use


  • Anti-Inflammatory Agents
  • Anti-Ulcer Agents
  • Astringents
  • Interleukin-8
  • Organometallic Compounds
  • Zinc Compounds
  • polaprezinc
  • Zinc Sulfate
  • Carnosine