Stress-induced hyperphagia and obesity in rats: a possible model for understanding human obesity

Science. 1976 Jan 23;191(4224):310-12. doi: 10.1126/science.1246617.


Mild tail pinch administered to rats several times daily in the presence of sweetened mild induced immediate hyperphagia and led to considerable gain in body weight. Parallels are drawn with stress-induced hyperhagia and altered affective states in obese humans.

MeSH terms

  • Animals
  • Castration
  • Dopamine / physiology
  • Estradiol / administration & dosage
  • Feeding Behavior / physiology*
  • Female
  • Obesity / etiology*
  • Rats
  • Stress, Physiological / complications*


  • Estradiol
  • Dopamine