Changes in sympathetic nerve activity of the mammalian ovary during a normal estrous cycle and in polycystic ovary syndrome: Studies on norepinephrine release

Microsc Res Tech. 2002 Dec 15;59(6):495-502. doi: 10.1002/jemt.10229.


Although it has been known for many years that the ovary is innervated by catecholaminergic nerve fibers and much experimental evidence has strengthened the notion that catecholamines are physiologically involved in the control of ovarian function, scarce evidence has been presented as to the role of sympathetic activity in ovarian pathologies that affect reproductive function. The purpose of this article is to provide a succinct overview of the findings in this area and discuss them relative to the pathology of polycystic ovary syndrome, the most common ovarian pathology in women during their reproductive years.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Estradiol / analogs & derivatives
  • Estradiol / metabolism
  • Estrous Cycle / physiology*
  • Female
  • Humans
  • Norepinephrine / metabolism*
  • Ovary / innervation*
  • Ovary / metabolism
  • Polycystic Ovary Syndrome / metabolism*
  • Polycystic Ovary Syndrome / pathology
  • Sympathetic Nervous System / physiopathology*


  • Estradiol
  • Norepinephrine