MyD88 as a bottle neck in Toll/IL-1 signaling

Curr Top Microbiol Immunol. 2002;270:155-67. doi: 10.1007/978-3-642-59430-4_10.

Abstract

Myeloid differentiation factor 88 (MyD88) is an adaptor molecule composed of an N-terminal death domain and a C-terminal Toll/interleukin (IL)-1R homology domain. Ligand binding to Toll-like receptor (TLR)/IL-1R family members results in the association of MyD88 to the cytoplasmic tail of receptors; this then initiates the signaling cascade that leads to the activation of nuclear factor-kappa B and mitogen-activated protein kinases. Analysis of MyD88-deficient mice revealed its essential role in TLR/IL-1R signaling as well as in both the innate and the adaptive immune response.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Animals
  • Antigens, Differentiation / immunology*
  • Drosophila Proteins*
  • Humans
  • Membrane Glycoproteins / immunology*
  • Mice
  • Myeloid Differentiation Factor 88
  • Receptors, Cell Surface / immunology*
  • Receptors, Immunologic / immunology*
  • Receptors, Interleukin-1 / immunology*
  • Signal Transduction / immunology*
  • Toll-Like Receptors

Substances

  • Adaptor Proteins, Signal Transducing
  • Antigens, Differentiation
  • Drosophila Proteins
  • MYD88 protein, human
  • Membrane Glycoproteins
  • Myd88 protein, mouse
  • Myeloid Differentiation Factor 88
  • Receptors, Cell Surface
  • Receptors, Immunologic
  • Receptors, Interleukin-1
  • Toll-Like Receptors