RORalpha: an orphan nuclear receptor on a high-cholesterol diet

Structure. 2002 Dec;10(12):1605-6. doi: 10.1016/s0969-2126(02)00916-4.

Abstract

A high-resolution X-ray crystal structure of the retinoic acid receptor-related orphan receptor (RORalpha; NR1F1), which reveals a molecule of cholesterol within the ligand binding pocket, is a breakthrough in functional analysis of this orphan nuclear receptor.

Publication types

  • News

MeSH terms

  • Cholesterol / chemistry*
  • Cholesterol / metabolism
  • Crystallography, X-Ray
  • Ligands
  • Nuclear Receptor Subfamily 1, Group F, Member 1
  • Protein Conformation
  • Receptors, Cytoplasmic and Nuclear / chemistry*
  • Receptors, Cytoplasmic and Nuclear / metabolism
  • Trans-Activators / chemistry*
  • Trans-Activators / metabolism

Substances

  • Ligands
  • Nuclear Receptor Subfamily 1, Group F, Member 1
  • Receptors, Cytoplasmic and Nuclear
  • Trans-Activators
  • Cholesterol