Zebrafish gastrulation movements: bridging cell and developmental biology

Semin Cell Dev Biol. 2002 Dec;13(6):471-9. doi: 10.1016/s1084952102001003.


During vertebrate gastrulation, large cellular rearrangements lead to the formation of the three germ layers, ectoderm, mesoderm and endoderm. Zebrafish offer many genetic and experimental advantages for studying vertebrate gastrulation movements. For instance, several mutants, including silberblick, knypek and trilobite, exhibit defects in morphogenesis during gastrulation. The identification of the genes mutated in these lines together with the analysis of the mutant phenotypes has provided new insights into the molecular and cellular mechanisms that underlie vertebrate gastrulation movements.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Movement / genetics
  • Embryonic and Fetal Development / genetics*
  • Gastrula / cytology*
  • Mutation
  • Signal Transduction
  • Zebrafish / embryology*
  • Zebrafish / genetics