Long-term follow-up of 246 adults with juvenile idiopathic arthritis: functional outcome

Rheumatology (Oxford). 2002 Dec;41(12):1428-35. doi: 10.1093/rheumatology/41.12.1428.


Objective: To examine the clinical and functional outcome of adults with juvenile idiopathic arthritis (JIA) using the recent World Health Organization/International League Against Rheumatism (ILAR) classification.

Patients and methods: Two hundred and fifty-nine adults with long-standing JIA (average disease duration 28.3 yr) were eligible for the study; 246 (95%) attended for an interview, clinical examination and notes review and 231 (89.2%) returned a comprehensive functional and psychosocial self-assessment questionnaire.

Results: Of all patients, 43.3% had active arthritis clinically and 54.4% on laboratory measures (C-reactive protein). Clinical inflammation was less common in systemic-onset JIA. The percentage of all patients with severe disability (Health Assessment Questionnaire score >1.5) was 42.9. Uveitis occurred frequently in the oligoarticular-onset and enthesitis-related subsets. Over 30% of the extended oligoarticular group with uveitis developed glaucoma compared with none of the enthesitis group.

Conclusions: Adults with JIA often have significant levels of disability, often related to continuing active disease over prolonged periods. There is a clear need for good transition from paediatric to high-quality adult rheumatology care.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age of Onset
  • Aged
  • Amyloidosis / complications
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Antibodies, Antinuclear / analysis
  • Antirheumatic Agents / therapeutic use
  • Arthritis, Juvenile* / complications
  • Arthritis, Juvenile* / immunology
  • Blood Sedimentation
  • C-Reactive Protein / analysis
  • Chronic Disease
  • Disability Evaluation
  • Female
  • Follow-Up Studies
  • Growth Disorders / complications
  • Health Status*
  • Humans
  • Immunoglobulin G / blood
  • Joints / physiopathology
  • Male
  • Middle Aged
  • Uveitis / complications


  • Anti-Inflammatory Agents, Non-Steroidal
  • Antibodies, Antinuclear
  • Antirheumatic Agents
  • Immunoglobulin G
  • C-Reactive Protein