Oligosaccharyl transferase: gatekeeper to the secretory pathway

Curr Opin Chem Biol. 2002 Dec;6(6):844-50. doi: 10.1016/s1367-5931(02)00390-3.


Oligosaccharyl transferase is part of the macromolecular machinery that processes nascent proteins in the endoplasmic reticulum. The enzyme is highly conserved, catalyzes the initial step in the biosynthesis of N-linked glycoproteins and acts as a 'gatekeeper' for the secretory pathway. As more proteins associated with oligosaccharyl transferase are identified, the intricacies of the enzyme and the relationship with other proteins in the lumen of the endoplasmic reticulum are starting to be unraveled.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Carbohydrate Metabolism, Inborn Errors / genetics
  • Carbohydrate Metabolism, Inborn Errors / metabolism
  • Carbohydrate Sequence
  • Endoplasmic Reticulum / enzymology
  • Glycoproteins / biosynthesis*
  • Glycoproteins / chemistry
  • Glycosylation
  • Golgi Apparatus / metabolism
  • Hexosyltransferases*
  • Humans
  • Membrane Proteins*
  • Molecular Sequence Data
  • Mutation
  • Protein Processing, Post-Translational*
  • Protein Transport
  • Saccharomyces cerevisiae
  • Sequence Homology, Amino Acid
  • Transferases / genetics
  • Transferases / metabolism*


  • Glycoproteins
  • Membrane Proteins
  • Transferases
  • Hexosyltransferases
  • dolichyl-diphosphooligosaccharide - protein glycotransferase