Anterior-posterior polarity in C. elegans and Drosophila--PARallels and differences

Science. 2002 Dec 6;298(5600):1946-50. doi: 10.1126/science.1072162.

Abstract

The eggs of Caenorhabditis elegans and Drosophila bear little similarity to each other, yet both depend on the par genes for control of anterior-posterior polarity. Here we explore possible common roles for the par genes (pars) in converting transient asymmetries into stably polarized axes. Although clear mechanistic parallels remain to be established, par-dependent regulation of microtubule dynamics and protein stability emerge as common themes.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Body Patterning
  • Caenorhabditis elegans / cytology
  • Caenorhabditis elegans / physiology*
  • Caenorhabditis elegans Proteins / physiology*
  • Cell Polarity*
  • Cytoplasm / physiology
  • Drosophila / cytology
  • Drosophila / physiology*
  • Drosophila Proteins / physiology*
  • Fertilization
  • Genes, Helminth
  • Genes, Insect
  • Microtubules / physiology
  • Oocytes / cytology
  • Oocytes / physiology
  • Oogenesis
  • Ovum / cytology
  • Ovum / physiology*
  • Protein Serine-Threonine Kinases / genetics
  • Protein Serine-Threonine Kinases / physiology
  • Zygote / cytology
  • Zygote / physiology

Substances

  • Caenorhabditis elegans Proteins
  • Drosophila Proteins
  • PAR-1 protein, C elegans
  • Protein Serine-Threonine Kinases