A revised picture of the E2F transcriptional network and RB function

Curr Opin Cell Biol. 2002 Dec;14(6):684-91. doi: 10.1016/s0955-0674(02)00388-5.


New techniques have enhanced our picture of E2F regulation. These studies have shed light on the roles played by individual E2F and retinoblastoma family members and implicate these proteins in processes extending well beyond the G1/S transition. One thorny issue remains: do our current molecular models of E2F and retinoblastoma action explain all of the functions of these proteins in vivo?

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Binding Sites
  • Cell Cycle Proteins*
  • DNA Damage
  • DNA Repair
  • DNA Replication
  • DNA-Binding Proteins*
  • E2F Transcription Factors
  • Gene Expression Regulation, Developmental
  • Mitosis
  • Models, Genetic
  • Promoter Regions, Genetic
  • Retinoblastoma Protein / physiology*
  • Transcription Factors / physiology*
  • Transcriptional Activation


  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • E2F Transcription Factors
  • Retinoblastoma Protein
  • Transcription Factors