Histone mRNA expression: multiple levels of cell cycle regulation and important developmental consequences

Curr Opin Cell Biol. 2002 Dec;14(6):692-9. doi: 10.1016/s0955-0674(02)00387-3.


Histone mRNA metabolism is tightly coupled to cell cycle progression and to rates of DNA synthesis. The recent identification of several novel proteins involved in histone gene transcription and pre-mRNA processing has shed light on the variety of mechanisms cells employ to achieve this coupling.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biological Evolution
  • Cell Cycle
  • Gene Expression Regulation*
  • Gene Expression Regulation, Developmental
  • Histones / biosynthesis
  • Histones / genetics*
  • Models, Genetic
  • Oogenesis
  • RNA Precursors / metabolism
  • RNA Processing, Post-Transcriptional
  • RNA Stability
  • RNA, Messenger / biosynthesis
  • RNA, Messenger / metabolism*
  • Signal Transduction
  • Transcription, Genetic


  • Histones
  • RNA Precursors
  • RNA, Messenger