The interdependence of nuclear structure and function

Curr Opin Cell Biol. 2002 Dec;14(6):780-5. doi: 10.1016/s0955-0674(02)00386-1.


2001 was the year of the human genome, but the new information has had little immediate impact on the field of nuclear structure. Rather, functional studies - especially on transcription - are leading us to a better understanding of how genomes might organise themselves into structures we call nuclei.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Nucleus / genetics
  • Cell Nucleus / physiology*
  • Cell Nucleus / ultrastructure*
  • Chromatin / ultrastructure
  • DNA Repair
  • DNA Replication
  • Humans
  • Models, Genetic
  • RNA Transport
  • Recombination, Genetic
  • Transcription, Genetic


  • Chromatin