A susceptibility gene for psoriatic arthritis maps to chromosome 16q: evidence for imprinting

Am J Hum Genet. 2003 Jan;72(1):125-31. doi: 10.1086/345646. Epub 2002 Dec 9.


Several genetic loci have been reported for psoriasis, but none has been specifically linked to psoriatic arthritis (PsA), a condition that affects >10% of patients with psoriasis. A genetic component for PsA is suggested by segregation within families and high concordance among identical twins. We performed a linkage scan to map genes contributing to PsA. We identified 178 patients with PsA out of 906 patients who were included in our genetic study of psoriasis. Using a comprehensive genealogy database, we were able to connect 100 of these into 39 families. We genotyped the patients using a framework marker set of 1,000 microsatellite markers, with an average density of 3 cM, and performed multipoint, affected-only, allele-sharing linkage analysis using the Allegro program. On the basis of the initial results, we genotyped more markers for the most prominent loci. A linkage with a LOD score of 2.17 was observed on chromosome 16q. The linkage analysis, conditioned on paternal transmission to affected individuals, gave a LOD score of 4.19, whereas a LOD score of only 1.03 was observed when conditioned for maternal transmission. A suggestive locus on chromosome 16q has previously been implicated in psoriasis. Our data indicate that a gene at this locus may be involved in paternal transmission of PsA.

MeSH terms

  • Alleles
  • Arthritis, Psoriatic / genetics*
  • Chromosome Mapping
  • Chromosomes, Human, Pair 16 / genetics*
  • Female
  • Genetic Predisposition to Disease / genetics*
  • Genomic Imprinting / genetics*
  • Humans
  • Lod Score
  • Male
  • Microsatellite Repeats / genetics

Associated data

  • OMIM/177900
  • OMIM/605956