The pathogenesis of atopic eczema

Hosp Med. 2002 Nov;63(11):653-6. doi: 10.12968/hosp.2002.63.11.1909.

Abstract

Atopic eczema is associated with a genetic predisposition to dysregulation of the immune system. T lymphocytes differentiate towards the Th2 type with promotion of immunoglobulin E antibodies. Allergic responses to environmental allergens develop and microbes, including staphylococci and pityrosporum yeasts, may contribute to the inflammatory process.

Publication types

  • Review

MeSH terms

  • Allergens / immunology
  • Dermatitis, Atopic / etiology*
  • Dermatitis, Atopic / genetics
  • Dermatitis, Atopic / immunology
  • Genes, MHC Class II / immunology
  • Humans
  • Immunoglobulin E / immunology
  • Interleukins / immunology
  • Skin / immunology
  • Skin / microbiology
  • Skin Tests / methods
  • T-Lymphocytes / immunology

Substances

  • Allergens
  • Interleukins
  • Immunoglobulin E