The Dof family of plant transcription factors

Trends Plant Sci. 2002 Dec;7(12):555-60. doi: 10.1016/s1360-1385(02)02362-2.


Dof proteins are members of a major family of plant transcription factors. The proteins have similar DNA-binding properties because of the highly conserved DNA-binding domain. However, recent studies are disclosing their diverse roles in gene expression when associated with plant-specific phenomena including light, phytohormone and defense responses, seed development and germination. Based on the structural diversity indicated by the complete catalog of Arabidopsis Dof proteins, Dof genes appear to have evolved multiple times, preceding and paralleling the diversification of angiosperms. Such gene multiplication might have led to the functional diversification of Dof proteins proceeding differently in distinct plant species.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Arabidopsis / genetics
  • Arabidopsis Proteins / genetics
  • Base Sequence
  • Binding Sites / genetics
  • DNA-Binding Proteins / genetics*
  • Evolution, Molecular
  • Molecular Sequence Data
  • Multigene Family / genetics*
  • Phylogeny
  • Plant Proteins / genetics*
  • Plants / genetics*
  • Transcription Factors / genetics*


  • Arabidopsis Proteins
  • DAG1 protein, Arabidopsis
  • DNA-Binding Proteins
  • Dof3 protein, Arabidopsis
  • Plant Proteins
  • Transcription Factors