Clonal spread among Swedish children of a Staphylococcus aureus strain resistant to fusidic acid

Scand J Infect Dis. 2002;34(10):729-34. doi: 10.1080/0036554021000026926.


An increased incidence of fusidic acid-resistant Staphylococcus aureus strains causing superficial infections among children in Sweden has been noted since the mid-1990s. Based on routine susceptibility testing data from 10 laboratories representing 8/21 Swedish counties during 1990-2001, the increase was first demonstrated in southern Sweden and subsequently became apparent throughout the country. Epidemiological typing using pulsed-field gel electrophoresis of recent isolates of fusidic acid-resistant S. aureus from 11 laboratories representing 8/21 Swedish counties revealed a high degree of similarity of band patterns, indicating a clonal relationship. Data from 1 of the laboratories demonstrated a close connection between this clone and impetigo. Sales statistics showed a pronounced increase in the use of fusidic acid ointments in the 0-12 y age group from 1998 onwards. There was, however, no statistically significant correlation between sales of fusidic acid ointments and resistance among S. aureus strains to fusidic acid.

MeSH terms

  • Administration, Topical
  • Age Distribution
  • Child
  • Child, Preschool
  • Drug Resistance, Microbial*
  • Electrophoresis, Gel, Pulsed-Field
  • Female
  • Fusidic Acid / pharmacology*
  • Humans
  • Impetigo / drug therapy
  • Impetigo / epidemiology*
  • Impetigo / microbiology
  • Infant
  • Male
  • Microbial Sensitivity Tests
  • Molecular Epidemiology
  • Ointments
  • Prevalence
  • Probability
  • Retrospective Studies
  • Sensitivity and Specificity
  • Sex Distribution
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / isolation & purification*
  • Sweden / epidemiology


  • Ointments
  • Fusidic Acid