Intracellular lipid binding proteins of the small intestine

Mol Cell Biochem. 2002 Oct;239(1-2):79-82.


The small intestine contains three distinct proteins belonging to the intracellular lipid binding protein family: the liver-type fatty acid binding protein (L-FABP), the intestinal fatty acid binding protein (I-FABP) and the ileal lipid binding protein (ilbp). The function of these proteins in the small intestine has remained enigmatic. Targeted gene disruption studies may shed insights into the physiological importance of these proteins. In the case of I-FABP, this approach has demonstrated that the complete elimination of this protein in murine intestine does not compromise dietary fat absorption in vivo but is associated with the development of insulin resistance.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism*
  • Dietary Fats / metabolism
  • Fatty Acid-Binding Protein 7
  • Fatty Acid-Binding Proteins
  • Intestinal Absorption / physiology
  • Intestine, Small / metabolism*
  • Mice
  • Mice, Knockout
  • Neoplasm Proteins*
  • Nerve Tissue Proteins*


  • Carrier Proteins
  • Dietary Fats
  • Fabp1 protein, mouse
  • Fabp5 protein, mouse
  • Fabp7 protein, mouse
  • Fatty Acid-Binding Protein 7
  • Fatty Acid-Binding Proteins
  • Neoplasm Proteins
  • Nerve Tissue Proteins