Different cytokines induce surface lymphotoxin-alphabeta on IL-7 receptor-alpha cells that differentially engender lymph nodes and Peyer's patches

Immunity. 2002 Dec;17(6):823-33. doi: 10.1016/s1074-7613(02)00479-x.


The formation of lymph nodes (LN) and Peyer's patches (PP) can be distinguished by the requirement of RANK for LN but not IL-7R(alpha), which is essential for PP development. However, lymphotoxin-alphabeta (LT(alpha)beta) signaling is required for both organs. The cellular basis underlying this dichotomy was revealed by the finding that the fetal IL-7R(alpha)(+) population responded equally well to IL-7 and RANKL to express LT(alpha)beta. IL-7R(alpha)(+) cells harvested from TRAF6(-/-) embryos expressed LTalphabeta in response to IL-7 but not RANKL, demonstrating that the RANK-TRAF6 signaling pathway regulates LT(alpha)beta expression in LN but not in PP. Soluble IL-7 administered to TRAF6(-/-) embryos was sufficient to restore LN genesis indicating the functional similarities of the IL-7R(alpha)(+) inducer cells for LN and PP genesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Lineage / immunology
  • Female
  • Lymph Nodes / immunology*
  • Lymphotoxin-alpha / biosynthesis
  • Lymphotoxin-alpha / immunology*
  • Lymphotoxin-beta
  • Membrane Proteins / biosynthesis
  • Membrane Proteins / immunology*
  • Mice
  • Mice, Inbred C57BL
  • Peyer's Patches / immunology*
  • Receptors, Interleukin-7 / immunology*
  • Signal Transduction / immunology


  • Ltb protein, mouse
  • Lymphotoxin-alpha
  • Lymphotoxin-beta
  • Membrane Proteins
  • Receptors, Interleukin-7
  • interleukin-7 receptor, alpha chain