A diffusion tensor MRI study of basal ganglia from patients with ADEM

J Neurol Sci. 2003 Jan 15;206(1):27-30. doi: 10.1016/s0022-510x(02)00310-6.


Using diffusion tensor (DT) MRI and histogram analysis, we measured mean diffusivity ((-)D) of basal ganglia grey matter (GM) from eight patients with acute disseminated encephalomyelitis (ADEM), 10 patients with multiple sclerosis (MS), and 10 healthy controls. Patients with ADEM had higher average (-)D (p=0.02) and lower (-)D histogram peak height (p=0.008) of the basal ganglia GM than patients with MS. Microscopic tissue damage occurs in the basal ganglia of ADEM patients, but not in MS patients with a similar burden of MRI-visible brain lesions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Basal Ganglia / pathology*
  • Encephalomyelitis, Acute Disseminated / pathology*
  • Female
  • Humans
  • Magnetic Resonance Imaging / methods
  • Male
  • Reference Values