Phage mediated horizontal transfer of the sopE1 gene increases enteropathogenicity of Salmonella enterica serotype Typhimurium for calves

FEMS Microbiol Lett. 2002 Dec 17;217(2):243-7. doi: 10.1111/j.1574-6968.2002.tb11482.x.

Abstract

Epidemiological evidence shows that the sopE1 gene is associated with Salmonella Typhimurium phage types causing epidemics in cattle. In this study we demonstrate that horizontal transfer of the sopE1 gene by lysogenic conversion with the SopEphi increased enteropathogenicity of S. Typhimurium in the bovine ligated ileal loop model. These data support the hypothesis that phage mediated horizontal transfer of the sopE1 gene contributes to the emergence of epidemic cattle-associated S. Typhimurium clones.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Bacterial Proteins / genetics*
  • Bacterial Proteins / metabolism
  • Bacteriophages / genetics*
  • Cattle
  • Cattle Diseases / microbiology*
  • Enterobacteriaceae / pathogenicity
  • Gene Transfer, Horizontal
  • Genes, Bacterial*
  • Intestines / microbiology
  • Intestines / pathology
  • Lysogeny / genetics
  • Male
  • Salmonella Infections, Animal / microbiology*
  • Salmonella typhimurium / genetics
  • Salmonella typhimurium / metabolism
  • Salmonella typhimurium / pathogenicity*

Substances

  • Bacterial Proteins
  • SopE protein, Salmonella