Knockdown stands up

Trends Biotechnol. 2003 Jan;21(1):2-4. doi: 10.1016/s0167-7799(02)00002-1.


In the past year, the genetic research of mammalian cells in vitro has gained the advantages of RNA interference (RNAi), a process found in worms and plants by which double stranded RNAs mediate selective gene inactivation through mRNA destruction. Recently, two papers have shown that genes could be suppressed in vivo in mammals by RNAi, which has potential implications for both therapeutics and research.

Publication types

  • Review

MeSH terms

  • Animals
  • Gene Silencing
  • Genetic Techniques*
  • Humans
  • Mice
  • Mice, Knockout
  • RNA Interference*