Clinical pharmacology of melphalan and its implications for clinical resistance to anticancer agents

Cancer Treat Res. 2002:112:305-22. doi: 10.1007/978-1-4615-1173-1_15.
No abstract available

Publication types

  • Review

MeSH terms

  • Alkylation
  • Antineoplastic Agents, Alkylating / pharmacology*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Apoptosis
  • DNA / metabolism
  • DNA Repair
  • DNA Topoisomerases, Type I / metabolism
  • DNA-Directed DNA Polymerase / metabolism
  • Drug Resistance, Neoplasm*
  • Glutathione / metabolism
  • Glutathione Transferase / metabolism
  • Humans
  • Melphalan / pharmacokinetics*
  • Melphalan / therapeutic use*
  • Neoplasms / drug therapy*

Substances

  • Antineoplastic Agents, Alkylating
  • DNA
  • Glutathione Transferase
  • DNA-Directed DNA Polymerase
  • DNA Topoisomerases, Type I
  • Glutathione
  • Melphalan