Microangiopathic hemolysis refractory to plasmapheresis responding to docetaxel and cisplatin: a case report

Med Oncol. 2002;19(3):189-92. doi: 10.1385/MO:19:3:189.

Abstract

We report the case of a 56-yr-old woman with adenocarcinoma of unknown origin metastatic to the bone marrow presenting with a thrombotic thrombocytopenic purpura-like syndrome refractory to protracted daily plasmapheresis and steroids but readily and completely responsive to docetaxel plus cisplatin. Sustained and complete response was pathologically confirmed.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / drug therapy
  • Adenocarcinoma / secondary
  • Anemia, Hemolytic / etiology
  • Anemia, Hemolytic / therapy*
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Bone Neoplasms / drug therapy
  • Bone Neoplasms / secondary
  • Cisplatin / administration & dosage
  • Cisplatin / therapeutic use*
  • Docetaxel
  • Female
  • Hemolysis
  • Humans
  • Methylprednisolone / therapeutic use
  • Middle Aged
  • Paclitaxel / administration & dosage
  • Paclitaxel / analogs & derivatives*
  • Paclitaxel / therapeutic use*
  • Plasmapheresis
  • Taxoids*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Taxoids
  • Docetaxel
  • Paclitaxel
  • Cisplatin
  • Methylprednisolone